HeadacheFree is the product of a board-certified neurologist's desire to find a safe and effective way to help patients pro-actively manage chronic headaches, every day, without over-reliance on prescription or over-the-counter drugs. HeadacheFree contains the FDA recommended amounts of daily vitamins and minerals. Plus HeadacheFree contains two ingredients – vitamin B2 (riboflavin) and magnesium – that have been clinically proven to reduce headache suffering.

In separate clinical trials, vitamin B2 has been shown to significantly reduce headache frequency, severity, duration and the incidence of nausea; magnesium has been shown to significantly reduce headache frequency and drug consumption for symptomatic treatment of headaches. Combining these ingredients with a multivitamin makes HeadacheFree a complete dietary supplement formulated to provide the optimal health and wellness benefit for the headache-prone – all from just two tablets a day.

Clinical Studies


A 3-month double-blind placebo-controlled study of 55 people with migraines, revealed that riboflavin can significantly reduce the frequency and duration of migraine attacks.1 This study found that, when given at least 2 months to work, a daily dose of riboflavin (400 mg) can produce dramatic migraine relief. The majority of the participants experienced a greater than 50% decrease in the number of migraine attacks as well as the total days with headache pain. However, a larger and longer study is needed to follow up on these results.

  • 1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology. 1998;50:466–470.


Preliminary research in a group of women (mostly premenopausal) showed that supplementing with magnesium (usually 200 mg per day) reduced the frequency of migraines in 80% of those treated.1 In a double-blind trial of 81 people with migraines, 600 mg of magnesium per day was significantly more effective than placebo at reducing the frequency of migraines.2 Another double-blind trial found that taking 360 mg of magnesium per day decreased the number of days on which premenstrual migraines occurred.

  • Weaver K. Magnesium and migraine. Headache 1990;30:168 [letter].
  • eikert A, Wilimzig C, Kohne-Volland R. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia 1996;16:257–63.
  • Facchinetti F, Sances G, Borella P, et al. Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache 1991;31:298–301

About the developer

Gary A. L'Europa MD, FASH has been treating complex headache patients since 1987. He is a graduate of The Brown University Alpert Medical School, completed his internship at Roger Williams Hospital and fulfilled his neurology training at UMass Medical Center. He is a Diplomat of the American Academy of Psychiatry and Neurology in Neurology, Clinical Neurophysiology and Headache Medicine. He is a Fellow of the American Headache Society, Physician Advisor to the National Headache Foundation Support Group.

In 1990 he founded NeuroHealth, a comprehensive, multidisciplinary medical center specializing in the diagnosis and treatment of neurological disorders where he serves as director. His medical staff includes four Specialized Nurse Practioners, Physical Therapists, a Behavioral Therapist and a Neuropsychologist. Together, they treat more headache patients than any other center in New England.

Dr L'Europa has been selected multiple times by his peers as a Top Doc in Rhode Island Monthly’s biannual survey. He is the past president of the Rhode Island Neurological Society, the Rhode Island Neurological Association, the Kent County Medical Society and currently serves on The Rhode Island Department of Health Board of Medical Review and Discipline.

Introducing improved formulary HeadacheFree

When you’re a vitamin/supplement maker, there’s always a balance between using the most natural ingredients and making a tablet size you can comfortably swallow. With our new formulary, we’ve created that balance.

Improved formulary HeadacheFree contains natural Vitamin E (derived from Vegetable Oils), Vitamin D (from Vegetable Oils), and Vitamin K (from Mulberry Leaf). Our vitamin A is now 100% beta carotene for optimal nutrient action and absorption. Plus we reduced the iron content (better for men, teens, and post-menopausal women) and eliminated heavy metals (better for us all).

All to bring you headache relief—combined with a complete multivitamin—in the smallest, gentlest, most natural form possible.

HeadacheFree Food-Based Advantage

HeadacheFree multivitamin is manufactured using food ingredients in their inherent recognizable form to support absorption of the nutrients this advanced formula delivers. No synthetic binders or fillers are used.

Why food-based is better. Foods contain specific compounds that help in the absorption and delivery of vitamins and minerals to the cells that need them. This delivery mechanism, defined as utilization, is the gateway to good health.

Vitamins in nature occur within a family of micro-nutrients (things like trace elements, enzymes, co-factors and other unknown factors) that help them absorb into the human body and function to their full potential.

HeadacheFree provides superior absorption and delivers more of the nutrients your body needs, along with the added riboflavin and magnesium that can help reduce headache suffering. HeadacheFree also excludes those co-nutrients that are known allergy and headache triggers. So just two multivitamins a day deliver optimum health and wellness benefits for the headache prone, without the side effects.

HeadacheFree is made using a blend of food-based, natural and best-grade synthetic ingredients to allow optimal nutrient absorption and the smallest possible dosage.

  • No starch or soy
  • No dairy, animal by-products or stearic acid
  • No salt, sugar, artificial flavoring/coloring
  • No digestible plastic or heavy metals

HeadacheFree Supplement Facts

Serving Size: 2 Tablets

Servings Per Container: 30


As a dietary supplement, take two tablets daily for a full 30 days. Tablets may be taken separately or both at once.

Ingredient Amount per serving %Daily
Vitamin A (100% Beta-carotene) 5000 IU 100
Vitamin C (as Calcium Ascorbate) 60 mg 100
Vitamin D (as D3 Cholcalciferol, from Vegetable Oils) 400 IU 100
Vitamin E (as D Alpha Tocopheryl Succinate, from Vegetable Oils) 30 IU 100
Vitamin K (as Phytonadione, from Mulberry Leaf) 25 mcg 31
Vitamin B1 (as Thiamine HCl) 1.5mg 100
B2 (as Riboflavin) 400 mg 23529
Vitamin B3 (as Niacinamide) 20 mg 100
Vitamin B6 (as Pyridoxine HCl) 2 mg 100
Folic Acid 400 mcg 100
Vitamin B12 (as Cyanocobalamin) 6 mcg 100
Biotin 30 mcg 10
Vitamin B5(as D-calcium Pantothenate) 10 mg 100
Calcium (as Calcium Phosphate / Ascorbate / Sulfate) 162 mg 16
Iron (as Ferrous Fumerate) 8 mg 44
Phosphorus (as Dicalcium Phosphate) 109 mg 11
Iodine (as Potassium Iodide) 150 mcg 100
Magnesium (as Magnesium Oxide / Sulfate) 400 mg 100
Zinc (as Zinc Oxide) 15 mg 100
Selenium (as Sodium Selenite) 20 mcg 29
Copper (as Copper Sulfate) 2 mg 100
Manganese (as Manganese Sulfate) 2 mg 100
Chromium (as Chromium Chloride) 120 mcg 100
Molybdenum (as Sodium Molybdate) 75 mcg 100
Chloride (as Potassium Chloride) 72 mg 2
Potassium (as Potassium Chloride) 80 mg 2
Boron (as Boron Citrate) 150 mcg *
Vanadium (as Vanadyl Sulfate Hydrate) 10 mcg *
Silicon (as Silicon Dioxide) 2 mg *
Lutein 250 mcg *